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12.4 Special Populations Renal Impairment:Fondaparinux elimination is prolonged in patients with renal impairment since the major route of elimination is urinary excretion of unchanged drug

Similarly, once the inducing agent is removed, the effects on hepatocytes may take a few weeks to resolve (time for the xenobiotic to be cleared and for enzymes to degrade)

3 This study demonstrated a combined prevalence of minimal, moderate and severe ED in 52% of non-institutionalized men aged 40 to 70 (Figure 1)

Additional research is needed to examine whether vitamin E supplementation has utility in the management of patients with mild-to-moderate cognitive impairments