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Moreover, in the murine inflammatory bowel disease model, a reduction in neutrophil migration was demonstrated through the blockade of the CD128 chemokine receptor (132)

Transfection of complementary DNAs for the heavy and light subunits of human gamma-glutamylcysteine synthetase results in an elevation of intracellular glutathione and resistance to melphalan

In this regard, substituents include oxo, halogen, heterocycle, CN, OR x , NR x R y , NR x C(O)R y , NR x SO 2 R y , C(O)R x , C(O)OR x , C(O)NR x R y , SO n R x and SO n NR x R y , wherein n is 0, 1 or 2, R x and R y are the same or different and independently hydrogen, alkyl or heterocycle, and each of said alkyl and heterocycle substituents may be further substituted with one or more of oxo, halogen, OH, CN, alkyl, OR x , heterocycle, NR x R y , NR x C(O)R y , NR x SO 2 R y , C(O)R x , C(O)OR x , C(O)NR x R y , SO n R x and SO n NR x R y

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