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The sulfonamide 41 , like 23 (HA08) and 37 (HFI 419) increases spine density in primary cultures of hippocampal neurons but is unfortunately a too poor inhibitor of IRAP and is demonstrating a Ki value of 540 nM

Research also highlights its potential to reduce oxidative stress markers in cardiac tissue, suggesting broader relevance in cellular stress studies

[DOI] [PMC free article] [PubMed] [Google Scholar] 276.Li N, Lewis P, Samuelson D, Liboni K, Neu J

Weve seen external swelling, internal fluid shifts, headaches, stiffness, and, in rare cases, isolation of pro-growth signaling that could theoretically interact with cancer biology

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