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One of the most common ways that glutathione can be depleted is through the regular consumption of alcohol

Consistent with this, glutaminolysis-derived -KG promotes M2 activation by increasing fatty acid oxidation and Jmjd3-dependent epigenetic reprogramming of M2-related genes 142

Consequently, we propose a hypothesis: under normal circumstances, astrocytes predominantly rely on glycolysis for energy production, but as the organism ages and encounters heightened inflammation and oxidative stress, they transition toward mitochondrial oxidative phosphorylation to meet energy demands