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Lastly, we found that the CC domain of ORP5 binds to PA in vitro (Guyard et al

(63) demonstrated that the DIO2 Thr92Ala polymorphism substantially reduces type 2 deiodinase activity, impairs local T4-to-T3 conversion, and is associated with lower serum T3 levels in patients treated with levothyroxine

notably, its ability to utilize methemoglobin and bacterial hemoproteins as a heme source provides a competitive advantage over resident gut microbes ( Bacteroides fragilis proteins like BfrA, potentially disrupting microbial mutualism in the gut and exacerbating dysbiosis ( P.g exhibits a pronounced tropism for the intestinal mucosa, demonstrating a higher adhesive capacity to intestinal epithelial cells compared to other oral bacteria like Prevotella intermedia , an action primarily mediated by its gingipain proteases ( The ectopic colonization of P.g acts as a primary instigator of profound gut microbiota dysbiosis