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Although the modulation of transcription through histone modification serves as a useful paradigm, the mechanisms that mediate the anticancer effects of HDIs are more complex, with many non-histone targets identified (Figure 2)

Internal proteins such as the polymerase subunits (PA, PB1, PB2), matrix and nucleoprotein can have conservation in sequence of 7797% within influenza A but much reduced conservation with influenza B species