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In the rat models tested, NGO was found to have improved akinesia symptoms and reduced contralateral rotations in response to apomorphine, which implied neuroprotection through increased tyrosine hydroxylase-positive cells in NGO-treated rats, suggesting preservation of dopaminergic neurons

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Importantly, no significant increase of fluorescence intensity in tumor region was observed even at 90 minutes after FITC-scr injection compared to control (data not shown)

Medication side effects were the major reason for withdrawal from the studies