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Given the significant intra- and inter-tumoral heterogeneity observed in GBM lesions, even within the same malignancy grade, a 2014 study investigated the metabolome of a large cohort of patients with newly diagnosed primary or recurrent gliomas (grades II-IV) using tissue samples

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10.1007/s11356-020-08947-2 161 WangY.LiN.YangJ.-J.ZhaoD.-M.ChenB.ZhangG.-Q.et al (2020)