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Ube-3a plays an important role in protein degradation and it has been shown that its shortage in the hippocampus of aged rats is associated with memory impairment (115)

Pakrashi S, Jain N, Dalai S, Jayakumar J, Chandrasekaran PT, Raichur AM, et al

Such hits include genetic factors, insulin resistance, lipotoxicity, mitochondrial dysfunction, endoplasmic reticulum stress, inflammation, gut microbiota dysbiosis, and adipose tissue dysfunction [12, 13] (Fig