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Nivolumab and pembrolizumab, both immune checkpoint inhibitors targeting programmed cell death protein 1 (PD-1), have also been approved as first-line treatments for advanced HCC

PMID: 34429404

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Ferroptosis resistance in tumor cells In addition to System X c /GSH/GPX4 axis, an antioxidant system that protect tumor cells from ferroptosis, a number of new mechanisms of ferroptosis resistance have been found in vivo and in vitro studies of drug-resistant solid tumors mentioned above, which are associated with a variety of metabolic enzymes