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2023:S2666-335X(23)00037-X

Carvalho-Paulo, D

J Biol Chem (2015) 290(51):3020411

What they found (summary): NAD+ levels decline linearly with age in all tissues Sirtuins are glucose sensors , activated during caloric restriction and fasting The decline in NAD+ leads to pseudohypoxia in aging cells Supplementation with NAD+ precursors in animal models restores sirtuin activity Therapeutic perspectives: NMN, NR, sirtuin activators, CD38 inhibitors Why it matters: This is the reference article for the entire field

By thoroughly examining the evidence, which includes both animal models and clinical studies, we have determined that the effects of prolonged ethanol exposure go beyond just behavioral changes