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The key histological abnormalities of AD include necrosis and apoptosis of VSMCs, fracture of elastic fibers, and degradation of extracellular matrix (ECM) (73).The thrombi formed within the false lumen indicates the presence of continued inflammation under the condition of atherosclerosis and chronic inflammation, and the higher risk of rupture in patients with inflammatory diseases demonstrates the importance of inflammation in AD (74)

DALY rates increased from 2.32 (95% UI, 0.30 to 5.95) per 100,000 in 1990 to 2.70 (95% UI, 0.36 to 6.83) per 100,000 in 2021, an increase of 16.26% (95% UI, 8.0427.07), with an EAPC of 0.50 (95% CI, 0.390.62)

The optimal threshold value was determined using the Youden index (J = sensitivity + specificity 1), and 95% confidence intervals for sensitivity and specificity were calculated

Protein kinase C (PKC) activators (PMA), HDAC and DNA methyl transferase (DNMT) inhibitors, chemotherapeutic agents and anti-IgG are among the known classes of lytic inducers