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PPAR- is a nuclear receptor that regulates different metabolic pathways and inflammatory responses, where activation of this receptor can interfere with TGF-1 signaling via the Smad pathway and suppress the production of inflammatory mediators by downregulating NF-B

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The generation of a variety of brain organoids that mimic subregions of the human brain, including the forebrain, hindbrain, hypothalamus, midbrain, and neocortex, has become a reality, as we described above, overcoming the previous lack of human neurological models (Kofman et al., 2022)