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Resistance mechanisms, such as GPX4 upregulation, further complicate treatment

Chem, 2010, 82, 70497052

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Materials and methods Animals All methods are reported in the paper in accordance with ARRIVE guidelines ( The animals used in this study were Wistar rats originating from the husbandry of the Department of Experimental Neuropathology of the Institute of Zoology and Biomedical Research, Jagiellonian University in Krakow

Moreover, diary intake of serine can facilitate YAP- and TAZ-driven glutamine and serine catabolism to sustain proline and glycine anabolism and promote collagen biosynthesis, which improves cardiovascular function in PAH rodent models (Rachedi et al., 2024) ( Figure 3d )