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Concurrently, the emergence of molecularly intelligent photosensitizers that change their photophysical or chemical behavior in response to lesion-specific cues (pH, enzymes, redox) exemplifies how analyte-sensing functionality can be built directly into imaging-therapeutic agents

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Payer BA, Reiberger T, Rutter K, et al

they probably occur in humans, but we never see them because they must be lethal in the human embryo as well