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doi: 10.1016/j.mcn.2017.05.005

Subsequently, safety concerns remain a major bottleneck restricting the clinical translation of current research

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Results Baseline characteristics A total of 57 participants were enrolled in the study and divided into a normal weight group ( n = 22) and an obesity group ( n = 35) according to BMI

Deficiency of 5-methyladenosine phosphorylase (MTAP), a key enzyme in polyamine metabolism in tumors, can accelerate the accumulation of 5-deoxy-5methylthioadenosine (MTA) in the TME, ultimately reducing the maturation of dendritic cells and the activation of T cells