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The central mechanism of epileptic seizure is the epileptogenesis process which occurs due to an imbalance between inhibitory and excitatory neurotransmitters (Li et al

doi: 10.1016/j.jchromb.2018.09.010

Acknowledgments The authors would like to thank the University of Iowa Viral Vector Core and Central Microscopy Research Facilityespecially Jian Shaofor technical assistance

22-23] Based on these findings, the CAFC disagreed that a skilled person would have believed that the process described in the 779 Patent would be a promising method of eliminating ABUKs