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However, limited patient response rates and immune-related adverse events remain major clinical challenges

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Yu Y, Yang W, Bilotta AJ, Zhao X, Cong Y, Li Y

Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer

For example, this promotes fibrogenesis in the liver worsening the course of underlying hepatic disorders, and a similar worsening effect is observed on the course of other chronic disorders apparently not directly linked to iron homeostasis such as metabolic and cardiovascular disorders (Pietrangelo, 2016)