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As a result, it elicits a robust antitumor immune response and suppresses distant metastasis ( Figure 12C )

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After exposition to inflammatory stimuli, macrophages secrete cytokines such as tumor necrosis factor (TNF), interleukins (IL), leukotrienes, and prostaglandins

An animal study on gut microbial composition revealed significant -diversity differences between chronic unpredictable mild stress (CUMS) rats and control rats (Meng et al., 2025), which aligns with observational findings (McGuinness et al., 2022)

Acute disseminated encephalomyelitis progressing to multiple sclerosis: are infectious triggers involved