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These changes involved the occurrence of dark degenerated neurons and vacuolated neuropil in addition to definitive features of apoptotic neurons and oxidative stress common under conditions of chronic stress and depressive states (Dobrek and Gowacka, 2023)

In the cardiovascular system, 1,25(OH) 2 D 3 vitamin form inhibits renin gene expression by affecting the cyclic AMP signaling, a pathway that shows a crucial activity in renin biosynthesis/release as a response to different physiological stimuli [198]

Conclusions Increasing studies support the beneficial effects of KO on skin health, including anti-aging, anti-inflammatory properties, and wound healing promotion, which have been preliminarily evaluated in clinical, animal, and cellular experiments (Tables 24)