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Indeed, the latter is solvent-exposed in the co-crystal structures of GSK3 bound to PPPpSPxpS 27 and is dispensable for GSK3 inhibition in vitro 26 , indicating a subsidiary role of CK1 in the direct inhibition of GSK3, but also posing the question why membrane-associated CK1 promotes canonical Wnt signaling

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Note: indexed curves are used to compare medium-term scenario trajectories when full absolute volumes are not publicly disclosed

Gionfra F, De Vito P, Pallottini V, Lin HY, Davis PJ, Pedersen JZ, et al