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In 2011, dimeric integrin targeting PDCs were designed (Kimura et al., 2011), which featured ortho -carboranes as center and two cyclic c(RGDfK) peptides that were separately conjugated via a butanoic acid linker to each carbon atom in the cluster (Figure 10A)

However, when we ingest collagen, we break it down into prolylhydroxyproline (Pro-Hyp) and hydroxyprolylglycine (Hyp-Gly)

In clinic, we dig deeper

CoV-Y is also tightly packed, but pAE indicates a clear divide between Y1 and CoV-Y at Gly1763 (see Fig 7B)

On the other hand, it must be stressed that the above values are averages and there might be significant spatial heterogeneity 57