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Some researchers find that thigh injections produce fewer injection site reactions, while others prefer the abdomen for its reliability

When GHK is coupled with copper, the peptide may quench the redox activity of copper, facilitating the non-toxic delivery of copper into the cells 46

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Separately, GHK-Cu has been found to stimulate fibroblast proliferation while upregulating genes for collagen, elastin, dermatan sulfate, chondroitin sulfate, and decorin key structural components of the skin's extracellular matrix and to modulate matrix metalloproteinases (MMPs) and their inhibitors, which supports balanced remodeling rather than excessive breakdown or fibrosis