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Buchovecky CM, Turley SD, Brown HM et al (2013) A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome

A higher metabolic rate can contribute to greater calorie expenditure, which is beneficial for weight management, even in the absence of exercise

Therefore, TRIDs may not be a suitable treatment option for RTT patients with certain nonsense mutations which are prone to NMD as the best responders will have high levels of target transcript