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Addition of 5 g/mL BPC-157 stimulated a morphological change in HUVECs without significantly increasing the tube network formation, whereby increasing the dose to 10 g/mL caused greater tube formation compared to control

Moreover, a reduction in pro-inflammatory cytokine IL-1-mediated vascular inflammation was observed in Nrf2-deficient ApoE -/- mice ( -/- and LDLR -/- mice expressing apoB-100 only (LDLR -/- ApoB 100/100 ) reduced atherosclerotic lesion development