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5.3 Diseases of the digestive system Damage to the intestinal mucosal barrier is the pathogenesis of many digestive disorders, and dysregulation of intestinal flora or metabolites can disrupt the normal immune balance in the intestinal tract and activate abnormal immune responses in the host, exacerbating intestinal inflammation and damage to mucosal tissues (Wang S

Dietary choline, TMAO, and intestinal microorganisms in vivo can potentially lead to thrombosis, and within the physiological range of TMAO concentration observed in human and animal models, the effect of TMAO on platelet function is dose-dependent

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Prior studies have explored that NAC is beneficial in some pulmonary diseases such as idiopathic pulmonary fibrosis and cystic fibrosis (Shen et al