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2012;19:S539548

Gluten-containing grains are important components of a balanced diet, providing essential complex carbohydrates, vitamins, minerals, and AAs (van Hees et al

While these provide ALA rather than direct EPA and DHA, they contribute to overall anti-inflammatory status and support hormone balance

Recent studies have shown that SIRT1 exerts a neuroprotective effect in MPP+-treated dopaminergic neurons, primarily through deacetylation of PKM2, which improves brain lactate homeostasis and upregulates PGC-1 expression, promoting mitochondrial biogenesis in MPP+-treated cells 8,41

To provide further support for the above experimental observations, the isothermal doseresponse CETSA (ITDR CETSA ) was also performed