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Next, a metabolic-syndrome study reported higher energy expenditure, increased fatty-acid oxidation, reduced fat-mass accumulation, and improved insulin sensitivity in mouse models

Similarly, a meta-analysis of nine observational studies in older adults found low serum vitamin B 12 concentration to be associated with increased risk for depression, with significant association only in women (100)

This makes them particularly beneficial for people with digestive issues, vegans, vegetarians, or those taking certain medications like metformin

these have not been systematically characterized