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In another study, He et al., [121] demonstrated that SOD or catalase gene delivery by polylipid nanoparticles injected via the portal vein 1 day prior to the warm I/R procedure resulted in high levels of the transgene enzyme activity in the liver, and markedly attenuated hepatic I/R injury [121]

2024;282(Pt 1):136794

The pharmacodynamic action of curcumin is dose-dependent, typically requiring higher concentrations to achieve therapeutic efficacy

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