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Hepatocyte-specific deletion of lysosomal acid lipase leads to cholesteryl ester but not triglyceride or retinyl ester accumulation

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Trontinemab, an anti-amyloid monoclonal antibody fused to a transferrin receptor-binding shuttle module designed to enhance receptor-mediated transcytosis, is currently being evaluated in Phase I/II clinical studies, with early data indicating substantially increased brain exposure compared with conventional antibodies ( It is worth noting that an important limitation in the translation of preclinical findings to humans is the heavy reliance on transgenic mouse models, particularly APP/PS1 and 5xFAD

It is this open structure that makes ice less dense than liquid water

This ratio is straightforward and makes the math simple, which in turn reduces the likelihood of making an error in measurement