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Ibarra C, Vicencio JM, Estrada M et al (2013) Local control of nuclear calcium signaling in cardiac myocytes by perinuclear microdomains of sarcolemmal insulin-like growth factor 1 receptors

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Unrestrained replication fork progression in oncogene-expressing cells defective in fork reversal is mediated by PRIMPOL Recent work has shown that the restart of R-loop-stalled forks via the MUS81-LIG4-ELL axis also requires the DNA primase-polymerase PRIMPOL 14 , which is known to mediate repriming of DNA synthesis downstream of DNA lesions that block replication fork progression 38,39,40

Based on individual gene expression results, aged sample replicates CMO303 (WT) and CMO306 ( Mda5 -/- ) were found to be unfit for further analysis and were excluded

Animal experiments were approved by the Wako Animal Experiment Committee in RIKEN (approval number: W2021-2-020(1))