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While there are concerns about kidney stones from high vitamin C doses, I have never seen this and question its validity, though it is mentioned in the literature

65 JiangL.KonN.LiT.WangS

2), ii14ii17 (2005)

This reduction suggests an adaptive physiological response to caloric restriction, characterized by metabolic downregulation aimed at conserving energy and preserving essential functions [59, 60]