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[116] The high aggregation rate of these mutant species may involve aggregation from a nativelike holo state, [113a] whereby mutations increase surface hydrophobicity or lower net protein charge from 7.37(0.05) per dimer at physiological pH (7.4),[ 77 , 117 ] promoting the formation of nativelike oligomers that undergo misfolding similar to that normally preceding aggregation

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[DOI] [PMC free article] [PubMed] [Google Scholar] 10.Kang E.A., Han Y.M., An J.M., Park Y.J., Sikiric P., Kim D.H., Kwon K.A., Kim Y.J., Yang D., Tchah H., et al

Further, cells in the absence of WRN have defects in DNA double-strand breaks, especially those bound with DNA replication fork arrest