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Small Molecules, Big Results: How JAK Inhibitors Have Transformed the Treatment of Patients with IBD

In addition, an adequate supply of GSH is beneficial to attenuate ferroptosis

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Curcumin has been shown in preclinical studies to lessen inflammation by preventing and regulating the tissue release of pro-inflammatory cytokines, such as IL-4, IL-8, IL-6, and TNF- [446]

This process subsequently contributes to activating the nuclear factor kappaB (NF-B) pathway, upregulated glutamine transporters such as SLC38A2 and SLC7A5, and ultimately increased glutamine metabolism in cancer cells [128]