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Proline synthesis and proline cycling participate in redox signaling, and targeting proline metabolism may be an effective adjunct cancer therapy (Phang, 2019)

Inhibition of extracellular signal-regulated kinase downregulates claudin-2 expression and alters paracellular permeability in mouse rectum CMT93-II cells

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Introduction Cisplatin (CDDP) has been the mainstay for the treatment of a broad spectrum of human malignancies since it was approved by the FDA about 30 years ago