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Proc Natl Acad Sci 115, 1083610844.Google Scholar Chen, L, Qiu, R, Wang, B et al

So if you absolutely have to use it because a patients INR is 11 (even if theyre not clinically bleeding) or a patients INR is 4 and theyre having nosebleeds, use as small of a dose as possible to get the patient back in a safe range and mitigate the bleeding