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In synergy with IL-36Ra, IL-36 promotes the intestinal inflammation through the NF-KB pathway, which maintains the homeostasis by balancing the pro- and anti-inflammatory responses in the TME (88)

In addition, the exosomes can provide innovative therapeutic applications such as delivery of chemotherapeutics, siRNA and miRNAs, targeting the certain receptors such as HER2 or integrins on the metastatic lesions as well as controlling the immune reactions

Tirzepatide, a dual GLP-1 and GIP receptor agonist, activates more metabolic pathways than semaglutide alone and has shown superior weight loss outcomes in head-to-head trials

While both methylcobalamin and cyanocobalamin are effective, methylcobalamin may offer unique advantages for neurological support

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