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Although ERK activation is generally associated with pro-survival signaling, it occurs alongside impaired apoptotic and transcriptional responses in SCA3, creating an imbalance that undermines neuronal fate determination

Newkirk, M.M., R

Therefore, arsenic ingestion may alter wound response and, specifically, MMP-9/TIMP-1 ratios in the lung

The authors underlined that this could be mediated by the reduction in caspase-3/7 activity, by the increase in the B-cell lymphoma 2/BCL-2-like protein 4 (BCL2/BAX) ratio and by the reduction in tumor protein 53 (TP53), caspase-3 (CASP3) and caspase-8 (CASP8) expression [82]

Nacev, B