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To identify kinase(s) that modify G6PD, we screened a library of inhibitors for intracellular or receptor Tyr kinases such as Dasatinib [41] (SRC and ABL family), Ponatinib [42] (ABL family), Ruxolitinib [43] (JAK family), Crizotinib [44] (c-Met family) and AZD4547 [45] (FGFR family), and found that Dasatinib and/or Crizotinib detectably abrogated glucose-deprivation-triggered G6PD Y249/Y322 phosphorylation (Fig

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PMC8619365

Interestingly, the co-administration of CoQ 10 and -tocopherol showed a more pronounced activity and promoted the SHBG release, justifying the enhancement of insulin tolerance, which is a condition associated with a reduced hepatic synthesis of SHBG