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Possible side effects include abdominal pain and bloating, diarrhea, and gout

P-glycoprotein is well known for decreasing the efficacy of various drug administrations due to its ability to export intracellular levels of absorbed drug to the cell exterior

However, this would probably only happen with a very high intake of aspartame

Biochemistry 37 , 47224730 (1998)

Moreover, TEVs may contain tumor antigens that can be presented to CD8 + T cells by LECs leading to their deletion, and thus contributing to the inhibition of tumor immunity (178) ( Figure 4C )