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SIRT4 knockdown has been demonstrated to enhance the mitochondrial capacity to improve FAO, thereby further increasing mitochondrial elongation through its regulation of mitochondrial fusion (Noone et al

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Preserving muscle while losing fat is a major therapeutic goal in obesity medicine, as loss of muscle mass can worsen metabolic function and long-term outcomes

Among the most commonly reported complications are fibrosis of the cervix, vagina, and surrounding connective tissue, leading to decreased elasticity, vaginal shortening, and stenosis [109,110,111]