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In a study involving more than 10,000 elderly individuals, long-term, high-dose NSAID therapy was associated with a significantly increased risk of progression of chronic kidney disease (Gooch 2007)

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In addition, SLC7A11 inhibitors such as erastin, which induce ferroptosis, significantly improve oxaliplatin sensitivity when used in combination with FOLFOX, highlighting the potential of metabolic interventions to reverse chemoresistance [159]

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