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This disruption leads to blocked acetylcholine synthesis and secretion, resulting in cognitive impairments and affecting mood and memory in C57BL/6 mice (Wang L

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Mutations in these enzymes underscore their developmental importance: Alkbh5 knockout female mice have impaired fertility owing to defective RNA metabolism in germ cells 139 , and loss-of-function mutations in FTO in mice cause growth retardation, abnormalities in brain and cardiac development, and increased perinatal lethality 140,141,142,143

But what does this mean for those in the lab

David did. Meanwhile, in his lab, Sinclair pushed his studies up the evolutionary chain into mice, and in 2006 published the paper that would change his life: a study showing that overweight rodents fed resveratrol aged slower and stayed healthier than ones that did not consume the substance