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Cross-sectional studies have linked high Mn concentrations in drinking water to attention deficits, increased aggression, and lower performance on math tests in children (Khan et al., 2011

Besides, berberine down-regulates the expression of acetylcholinesterase and inhibits acetylcholinesterase activity in Alzheimers disease model mice hippocampus which induced by heavy metals, in addition, berberine normalizes the production of inflammatory factors, such as tumor necrosis factor-alpha (TNF-), IL-6, IL-1 (Hussien et al., 2018)

ROS also contributes significantly to inflammation in various illnesses by modulating transcription factors like NF-B and activator protein 1 (AP-1) through nuclear histone acetylation and deacetylation (295)