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Figure 1 mTORC1 is activated via growth factors stimulation [epidermal growth factor (EGF), insulin-like growth factor (IGF)], increase in amino acid levels such as leucin and arginine and cellular energy status ( On the other hand, mTORC2 is activated by growth factors but unlike mTORC1 its activity is not regulated by amino acids

There are two limitations to translating these findings

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Alpha-synuclein and the Parkinsons disease drug pipeline