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The drugs widely used in the clinical treatment of AD include acetylcholinesterase inhibitors and NMDA receptor antagonists, primarily for symptomatic treatment (Kabir et al., 2020)

Ozaki et al., 2018), and NQO1 ( CBS, CSE , and NQO1 mRNA levels (Figure 4)

doi: 10.3389/fphar.2021.757508 202 ZhangL.ZhaoM

High K + -induced depolarization amplifies neuroprotection provided by UA through a mechanism involving Ca 2 elevation and extracellular signal-regulated kinases (ERK 1/2 ) activation ( Figure 3 )

It aims to systematically elucidate the underlying molecular mechanisms, evaluate the implications for clinical diagnosis and therapeutic applications, and thereby offer novel perspectives and directions for future research in this domain