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Most anticancer nano-drug carriers prepared with PPE rely on the enhanced permeability and retention (EPR) effect for passive targeting, which has limitations, such as uneven distribution within tumor tissues or incomplete drug release (Gawali et al., 2023

Pheomelanin, on the other hand, is responsible for red and yellow hues

The physiological balance of ROS Under normal physiological conditions, the production and elimination of intracellular ROS are dynamically balanced through different pathways so that ROS can be constantly maintained at relatively low levels [13]