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In organotypic midbrain-striatum co-cultures increase in midbrain SOD activity increases the resistance of dopaminergic neurons to NO cytotoxicity via suppressing the formation of peroxynitrite (Katsuki et al., 2001)(Tabrizi et al., 2020)

Beyond dermatologic and visual symptoms, severe depletion of this nutrient causes significant ocular surface changes, including Bitot spots , which are characteristic foamy plaques on the bulbar conjunctiva