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To establish a mouse model of hypercholesterolemia-induced atherosclerosis, we fed 8-week-old male LDLR / mice D12108 feed containing 1.25% cholesterol for 8 weeks

2.7 LPS: TLR4-mediated inflammatory balance LPS, a component of Gram-negative bacterial outer membranes, activates TLR4/MyD88 signaling to trigger inflammatory responses (28, 29)

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