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[DOI] [PMC free article] [PubMed] [Google Scholar] 105.Ookhtens M., Lyon I., Fernndez-Checa J.C., Kaplowitz N

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Taking enzyme-responsive nanomaterials as an example, there are notable physiological and tumor microenvironment differences between animal models and human models in preclinical biosafety evaluations, complicating their clinical translation (Cao et al., 2019)